Back in New York City, Howard struggles to make sense of his new life as a human. And when Dr. Bong discovers that Howard survived, he vows once and for all to end Howard’s existence! How will Howard the Duck finally stop the relentless Dr. Bong!?

Howard roams the streets of Manhattan, trying to deal with his new existence as a "hairless ape" by interacting with the other humans of the city!

Note: Fifi only appears on a newspaper headline.